SidaGhanaV1, Main, Exploration, bibRecord, 001087

Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia

Identifieur interne : 001087 ( Main/Exploration ); précédent : 001086; suivant : 001088

Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia

Auteurs : Andrew Carr [Australie] ; Adrienne Morey [Australie] ; Patrick Mallon [Australie] ; David Williams [Australie] ; David R. Thorburn

Source :

The Lancet [ 0140-6736 ] ; 2001.

RBID : ISTEX:8401EFE73F8B3A76AAD2C0F19F2C9F4BEF732A6D

Descripteurs français

Wicri :
- topic : Migrant.

English descriptors

Abstract

Acute hepatitis with lactic acidosis is a life-threatening but reversible toxic effect on mitochondria of HIV-1 nucleosideanalogue treatment. We report fatal portal hypertension, liver failure, and persistent mitochondrial dysfunction in a man aged 65 years with HIV-1 infection who had recovered fromnucleoside-analogue-induced acute hepatitis and lactic acidaemia more than 18 months previously. We believe that symptomfree patients who receive nucleoside-analogue therapy should have hepatic function constantly monitored, especially those with past or present lactic acidaemia. Acute hepatitis with lactic acidosis is a toxic effect of HIV- 1 nucleoside analogues on mitochondria. 80 of patients with lactate greater than 10 mmol/L die. The longterm outcome of those who survive is unknown, but all reports have shown full recovery.

Url:

https://api.istex.fr/document/8401EFE73F8B3A76AAD2C0F19F2C9F4BEF732A6D/fulltext/pdf

DOI: 10.1016/S0140-6736(00)04579-7

Affiliations:

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Le document en format XML

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<term>Present lactic acidaemia</term>
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<term>Prevalence rates</term>
<term>Prothrombin time</term>
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<term>Recent migrants</term>
<term>Research letters</term>
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<front><div type="abstract">Acute hepatitis with lactic acidosis is a life-threatening but reversible toxic effect on mitochondria of HIV-1 nucleosideanalogue treatment. We report fatal portal hypertension, liver failure, and persistent mitochondrial dysfunction in a man aged 65 years with HIV-1 infection who had recovered fromnucleoside-analogue-induced acute hepatitis and lactic acidaemia more than 18 months previously. We believe that symptomfree patients who receive nucleoside-analogue therapy should have hepatic function constantly monitored, especially those with past or present lactic acidaemia. Acute hepatitis with lactic acidosis is a toxic effect of HIV- 1 nucleoside analogues on mitochondria. 80 of patients with lactate greater than 10 mmol/L die. The longterm outcome of those who survive is unknown, but all reports have shown full recovery.</div>
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Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia

Fatal portal hypertension, liver failure, and mitochondrial dysfunction after HIV-1 nucleoside analogue-induced hepatitis and lactic acidaemia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri